OxStem Neuro will identify a new class of drugs that will stimulate de novo neuron production from neural stem cells that will compensate for disease pathology in neurodegenerative diseases, and restore cognitive function.
There are drug treatments for neurodegenerative disease that can temporarily alleviate some symptoms or slow down their progression in some people, however OxStem Neuro’s approach aims to significantly reduce the impact of these diseases on cognitive function, by replenishing the lost neurons.
Two main nests of neural stem cells in the brain have been identified in the Subventricular Zone and the Dentate Gyrus of the hippocampus. OxStem Neuro will identify small molecules to augment the brain’s innate regenerative capacity. This will greatly improve the standard of living of those with neurodegenerative disease and would mark a large improvement over current treatments.