Professor Angela J. Russell gained her M.Chem. degree from the University of Oxford in 2000 and her D.Phil. in Organic Chemistry in 2004 under the joint supervision of Steve Davies and Tim Perera from Yamanouchi plc (now Astellas Pharma Inc.). In March 2006 she became a Departmental Research Lecturer in Organic Chemistry and in July 2007 was awarded a prestigious Research Councils’ UK Fellowship in Medicinal Chemistry jointly between the Departments of Chemistry and Pharmacology in Oxford. In 2012 she was appointed as University Lecturer, and in 2014 became an Associate Professor of Medicinal Chemistry. Angela’s research interests broadly encompass the development of small molecules to control developmental processes. Angela has realised several successful multidisciplinary research collaborations, including identifying small molecules to upregulate utrophin for the treatment of Duchenne Muscular Dystrophy, developing novel inhibitors and activators of developmental signaling pathways and new anti-cancer agents. Since 2005 Angela has initiated a number of collaborative programmes involving the discovery and development of small molecules to manipulate stem cell fate. Angela’s work has resulted in >60 publications and patent filings to date.
In addition, Angela has founded two University spin out companies: MuOx Ltd in 2012, which was acquired by Summit plc in 2013, and OxStem Ltd in 2014.
Professor Dame Kay Davies obtained her BA in 1973 and D.Phil. in 1976 from the University of Oxford. Kay is Dr Lee's Professor of Anatomy and Associate Head, Medical Sciences Division, University of Oxford, and Honorary Director of the MRC Functional Genomics Unit. Her research interests cover the molecular analysis of neuromuscular and neurological disease, particularly Duchenne Muscular Dystrophy. She has an active interest in the ethical implications of genetics research and the public understanding of science. She has considerable experience of biotechnology companies as a conduit for translating the results of experimental science into new therapeutics and diagnostics. She is a founding editor of 'Human Molecular Genetics' and a founding fellow of the Academy of Medical Sciences. Kay is also a Fellow of the Royal Society (2003) and a Member of the European Molecular Biology Organization. Kay joined the Board of Governors of the Wellcome Trust in January 2008 and became Deputy Chair in 2013.
Kay is a Dame Commander of the British Empire (DBE) since 2008, Commander of the British Empire (CBE) since 1996 and Fellow of the Academy of Medical Sciences (FMedSci) since 1998.
Professor Steve Davies obtained his BA in 1973 from the University of Oxford and his D.Phil. in 1975. He subsequently held an ICI Postdoctoral Fellowship (1975-1977) and a NATO Fellowship (1977-1978) before joining the CNRS at Gif-sur-Yvette as Attaché de Recherche. In 1980 he returned to Oxford to take up a University Lectureship in Chemistry. In 1996, he became Professor of Chemistry (Oxford) and in 2006, the Waynflete Professor of Chemistry (Oxford).
Whilst remaining an active academic, Davies founded Oxford Asymmetry Ltd (an asymmetric synthesis company) in 1991 as sole investor. He also founded Oxford Diversity Ltd (a combinatorial chemistry company). These two companies were merged to form Oxford Asymmetry International Plc in 1999 which was sold to Evotec in 2000 for £316m. In 2003 he founded VASTox (Value Added Screening Technology Oxford), a zebrafish screening company. It floated on AIM in 2004 and changed its name to Summit plc in 2007. Summit raised £23m in a follow-on offering in 2014 in order to conduct phase 2 studies of a utrophin modulator, discovered in Davies’ lab, in Duchenne Muscular Dystrophy and an in-licensed small molecule for the treatment of Clostridium difficile. In addition, Davies is founder and editor-in-chief for Tetrahedron: Asymmetry.